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Více informací o knize Biodegradable Gels of Insulin

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Anotace knihy

The objective of the study was to develop a controlled release dosage form of insulin, which can provide basal concentrations of insulin in diabetic rats for 1 to 2 weeks after a single subcutaneous injection. A biodegradable injectable drug delivery gel was prepared by dissolving a biodegradable polymer, polylactic-co-glycolic acid (PLGA), in biocompatible plasticizer(s), triethyl citrate (TEC) and/or acetyl triethyl citrate (ATEC). Insulin or modified insulin was then loaded into the blank gel to form insulin or modified insulin suspension in the polymer solution. After the insulin-loaded gel was injected subcutaneously, the insulin or modified insulin was released slowly from the depot by a combination of drug diffusion and erosion of the polymer. The formulation prepared with 5% PLGA, ATEC: TEC (3:1) and 4% modified insulin glargine was able to suppress the blood glucose concentrations of the ZDF rats significantly for 10 days after a single subcutaneous injection. The addition of zinc sulfate to the formulations prepared with purified insulin glargine particles further slowed down the drop in blood glucose concentrations.

Parametry knihy

Zařazení knihy Knihy v angličtině Mathematics & science Biology, life sciences Life sciences: general issues

• Plný název: Biodegradable Gels of Insulin
• Podnázev: CONTROLLED RELEASE OF INSULIN
• Autor: Om Anand, Atul J. Shukla
• Jazyk: Angličtina
• Vazba: Brožovaná
• Počet stran: 132
• EAN: 9783639217773
• ISBN: 3639217772
• ID: 06829639
• Nakladatelství: VDM Verlag
• Hmotnost: 204 g
• Rozměry: 229 × 152 × 8 mm
• Datum vydání: 23. April 2010

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