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Více informací o knize DNA Methylation and Cellular Differentiation

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Anotace knihy

In 1977 I wrote a grant proposal in which I applied to study developmental patterns in enzymatic methylation of DNA in eukaryotes. One part of the proposal was to assay cells at different embryonic developmental stages for maintenance and de novo type methylase activity. With one exception the referees, probably developmental biologists, recommended that the work not be supported because there was no evidence that methylation plays any role in eukaryotic gene regulation. Aside from proving that innovative ideas can seldom be used to successfully compete for grant funds, the skepticism of biologists toward methylation as a regulatory mechanism was, and still is, widespread even among some of those who investigate the problem. That is a healthy situation for all points of view should be brought to bear on a problem of such importance. However, to deny funds to investigate a problem because one has already formed an opinion without evidence is hardly commendable. The great skepticism about the significance of DNA methylation is based in part on the evidence that it is absent or very little used in Drosophila, a favorite organism for genetic and developmental studies. There now remains little doubt that methylation of cytosine in certain CpG sites can strikingly affect the transcription of sequences 3' to the methylated doublet. How this inhibition operates and to what extent it is utilized in cells is still debatable.

Parametry knihy

Zařazení knihy Knihy v angličtině Mathematics & science Biology, life sciences Biochemistry

• Plný název: DNA Methylation and Cellular Differentiation
• Autor: James H. Taylor
• Jazyk: Angličtina
• Vazba: Brožovaná
• Počet stran: 138
• EAN: 9783709187234
• ISBN: 3709187230
• ID: 02119094
• Nakladatelství: Springer Verlag GmbH
• Hmotnost: 276 g
• Rozměry: 244 × 170 × 9 mm
• Datum vydání: 30. December 2011

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