Kód: 07148083
The protein folding problem , i.e. understanding the§detailed steps §of the protein folding pathways is one of the most§challenging topics §in biochemistry. Combining theoretical with§experimental research §became indispensable f ... celý popis
Nákupem získáte 162 bodů
The protein folding problem , i.e. understanding the§detailed steps §of the protein folding pathways is one of the most§challenging topics §in biochemistry. Combining theoretical with§experimental research §became indispensable for the investigation of the§mechanisms in §protein folding reactions. §Here, the biophysical characterization of designed§ankyrin repeat §(AR) proteins and the analysis of the experimental§data by §theoretical models are presented. Repeat proteins§comprise §repeating structural units that form linear§multirepeat arrays. The §non-globular elongated structure distinguishes them§fundamentally §from most studied proteins and makes repeat proteins§interesting §for folding studies. §In a previous work, a full-consensus ankyrin repeat§had been §designed. Such an idealized ankyrin repeat served as§a model repeat §to study the folding mechanism of ankyrin repeat§proteins.
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