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Více informací o knize Pd-Catalyzed Cross-Coupling Strategies in Thiazole Chemistry

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Anotace knihy

Within this contribution the synthesis of anilino-substituted bithiazoles as potentially bioactive compounds is reported. The key chemical transformations in the applied synthetic strategy were Pd-catalyzed cross coupling reactions which were used for the formation of various bithiazoles. Different cross coupling methodologies were investigated. Starting from 2-thiazolamine the desired metal organyls were prepared in two steps. Besides the well documented Stille and Negishi reaction on thiazole derivatives, a new method could be established. After successful preparation of the first thiazoleboronic acid ester, Suzuki-Miyaura reactions were performed. Upon reaction with various bromo-thiazoles the desired bithiazole derivatives were obtained, whereby the Stille reaction gave the best results compared to the other two methods. Subsequently the chloro atom was used for a nucleophilic exchange reaction with aniline derivatives to give the target compounds.

Parametry knihy

Zařazení knihy Knihy v němčině Naturwissenschaften, Medizin, Informatik, Technik Chemie

• Plný název: Pd-Catalyzed Cross-Coupling Strategies in Thiazole Chemistry
• Podnázev: Synthesis of Arylated Thiazoles and Bithiazole Building Blocks
• Autor: Michael Schnürch
• Jazyk: Němčina
• Vazba: Brožovaná
• Počet stran: 292
• EAN: 9783838112466
• ID: 07086910
• Nakladatelství: Südwestdeutscher Verlag für Hochschulschriften
• Hmotnost: 453 g
• Rozměry: 220 × 150 × 19 mm
• Rok vydání: 2009

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