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Anotace knihy

This volume focuses on mitochondrial RNA metabolism, emphasizing recent discoveries and technological advances in this fast moving area that increase our understanding of mitochondrial gene function. Topics addressed include the interplay of mitochondria with the nucleus and cytosol, structure-function connections, and relevance to human disease. Mitochondria are the powerhouses of the cell, and a great deal is known about mitochondrial energy metabolism. Less well known is the plethora of amazing mechanisms that have evolved to control expression of mitochondrial genomes. Several RNA processes and machineries in protozoa, plants, flies and humans are discussed, including: translation and mitochondrial ribosome structure; transcription and RNA polymerase mechanism; tRNA processing of 5' and 3' ends; mRNA maturation by nucleotide insertion/deletion editing and by RNA splicing; mRNA stability; and RNA import. Specialized factors and ribonucleoproteins (RNPs) examined include pentatricopeptide repeat (PPR) proteins, RNase P, polymerases, helicases, nucleases, editing and repair enzymes. Remarkable features of these processes and factors are either not found outside mitochondria, differ substantially among eukaryotic lineages, or are unique in biology.

Parametry knihy

Zařazení knihy Knihy v angličtině Medicine Pre-clinical medicine: basic sciences Medical genetics

• Plný název: RNA Metabolism in Mitochondria
• Autor: Jorge Cruz-Reyes, Michael W. Gray
• Jazyk: Angličtina
• Vazba: Pevná
• Počet stran: 249
• EAN: 9783319781891
• ISBN: 3319781898
• ID: 19012810
• Nakladatelství: Springer International Publishing AG
• Hmotnost: 559 g
• Rozměry: 235 × 155 × 20 mm
• Datum vydání: 22. June 2018

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