Mohlo by se vám také líbit

Více informací o knize Viral Interference of GB Virus C and Human Immunodeficiency Viruses

• Parametry knihy
• Anotace
• Oblíbené z jiného soudku

Nákupem získáte 185 bodů

Anotace knihy

In general, infection of a host by multiple pathogens has important clinical implications. In conjunction with HIV, co-infections are associated with a significantly decreased survival probability. Unexpectedly, long-term viremia of the apathogenic GB Virus C (GBV-C) leads to improved survival of GBV-C co-infected HIV patients. However, epidemiological studies cannot prove a causal relationship nor they distinguish whether the observed reduction in HIV associated morbidity and mortality is caused by GBV-C/HIV interference or if GBV-C serves just as a surrogate marker for a robust immune system. Therefore, cell culture experiments were necessary. Indeed, GBV-C inhibits different HIV strains and clades. The underlaying mechanism of HIV suppression is complex. In addition to GBV-C proteins, such as the E2 glycoprotein that possess the ability to inhibit HIV entry or the NS5A protein that may imair later HIV replication steps, GBV-C elicits antibodies that neutralize HIV comparable to the broad reactive human anti-gp41 antibodies 2F5 and 4E10, as well. Taken together a combination of both inhibitory effects present an innovative approach for further drug development and vaccine design.

Parametry knihy

Zařazení knihy Knihy v angličtině Medicine Clinical & internal medicine Diseases & disorders

• Plný název: Viral Interference of GB Virus C and Human Immunodeficiency Viruses
• Podnázev: Different GB Virus C Proteins interfere with the Replication of HIV-1
• Autor: Susan Jung
• Jazyk: Angličtina
• Vazba: Brožovaná
• Počet stran: 124
• EAN: 9783838123837
• ISBN: 3838123832
• ID: 06976683
• Nakladatelství: Sudwestdeutscher Verlag Fur Hochschulschriften AG
• Hmotnost: 191 g
• Rozměry: 229 × 152 × 9 mm
• Datum vydání: 01. February 2011

Oblíbené z jiného soudku

---

---

---