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Více informací o knize Viral Proteins Counteracting Host Defenses

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Anotace knihy

Since the first observations of viral interference with antigen presentation in the MHC class-I pathway, the field has advanced to a detailed analysis. We know numerous genes and for some of them we have profound information on their mechanistic function. The antigen presentation pathway is affected at all stages starting from proteasomal degradation of an antigenic viral protein, as shown for EBV, transfer of the proteasomal cleavage products as peptides in the ER by specific transporters, the loading of the nascent MHC class-I molecule, and finally the transport of the complex to the surface and presentation in a normal or deranged form. All these different steps of the MHC class-I antigen presentation pathway are targets for viral proteins. Not only MHC class-I but also MHC class-II proteins are a target of viral influence either by direct downregulation and degradation of proteins or by interference of signal transduction pathways. Viruses that establish long-term or even lifelong infections have evolved sophisticated strategies to counteract a powerful host immune response. Bringing large DNA viruses like adenoviruses and herpesviruses into focus, this book documents a variety of such mechanisms, indicating a very active area of research over the last few years. The repertoire of viral mechanisms interfering with immune functions includes proteins that target antigen presentation pathways to prevent immune recognition or molecules mimicking soluble mediators ("virokines") or chemokine receptors. In view of the highly redundant immune effector mechanisms, the viral functions can teach us the relative biological significance of host defense strategies. Selected and optimized during evolution, the viral inhibitors now serve as unique tools which are perfectly designed to elucidate the molecular anatomy of the pathways that guide immune responses.

Parametry knihy

Zařazení knihy Knihy v angličtině Medicine Clinical & internal medicine Diseases & disorders

• Plný název: Viral Proteins Counteracting Host Defenses
• Autor: H. Hengel, U. H. Koszinowski
• Jazyk: Angličtina
• Vazba: Brožovaná
• Počet stran: 325
• EAN: 9783642639746
• ISBN: 9783642639746
• ID: 06625191
• Nakladatelství: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
• Hmotnost: 522 g
• Rozměry: 235 × 155 × 19 mm
• Datum vydání: 14. October 2011

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